Electronic clinical quality measure (eCQM) concordance and quality care disparities among patients with breast cancer (BC)

Pts actively treated for BC in 2021 in CancerLinQ data were included in this study. The following four practice-level eCQMs were assessed as proportions of BC pts who: eCQM1 – Undergo HER2 testing eCQM2 – Are < age 70 with early-stage, hormone receptor (HR) negative BC who receive combination chemotherapy < 4 months of dx eCQM3 – Have early-stage, HER2+ BC and receive trastuzumab eCQM4 – Have early-stage, HR+ BC and receive tamoxifen or an aromatase inhibitor (AI) < 1-year of dx Ethnicity, race, age at dx, pt/practice rural status, and practice type were assessed as covariates. Adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) were calculated for associations among study variables and receipt of guideline non-concordant care.

aORs (95% CI) of pt characteristics were compared to reference groups - non-Hispanic, white, age at dx 60-69, married, urban: eCQM1 (N = 21296): For unknown ethnicity, aOR (95% CI) = 1.5 (1.3 1.6); unknown race = 1.3 (1.2, 1.5); age 70-79 = 1.1 (1.0, 1.2), age 80-89 = 1.4 (1.2, 1.5), age > 90 = 1.5 (1.1, 2.2); formerly married/partnered = 1.2 (1.1, 1.3), thus having greater odds of non-concordance. Age 40-49, aOR (95% CI) = 0.9 (0.8, 0.986), had lower odds of non-concordance. eCQM2 (N = 1259): For unknown ethnicity, aOR (95% CI) = 1.9 (1.2, 3.1); Asian = 2.9 (1.7, 4.9) or other race = 2.3 (1.2, 4.1); and formerly married/partnered = 1.7 (1.2, 2.6), thus having greater odds of non-concordance. Pts age < 40 = 0.6 (0.3, 0.9) had lower odds of non-concordance. eCQM3 (N = 1341): Age > 80, aOR (95% CI) = 3.8 (1.5, 9.1), had greater odds of non-concordance. eCQM4 (N = 5063): For age < 40, aOR (95% CI) = 2.9 (2.1, 4.1), age 40-49 = 1.6 (1.2, 2.0), and age 50-59 = 1.5 (1.2, 1.9); and formerly married/partnered = 1.3 (1.1, 1.7), thus having greater odds of non-concordance.

As expected, pts < 40 had greater odds of receiving chemotherapy and pts > 80 had lower odds of receiving trastuzumab, possibly due to cardiotoxicity concerns. Although all women with early-stage HR+ BC are potential tamoxifen/AI candidates, pts < 60 with early-stage HR+ BC had greater odds of not receiving tamoxifen/AI compared to those age 60-69. Additionally, divorced, separated, or widowed pts had greater odds of non-concordant care in 3 of 4 of eCQMs assessed. Our findings demonstrate the ability of eCQMs to identify clinical subgroups more likely to receive non-concordant care who may be eligible for targeted interventions.